Bottom placed Tooro United start their journey without their star man Marvin Oshaba when they host fellow strugglers Onduparaka FC at Buhinga Stadium in Fort Portal.
Oshaba left the Fort Portal based entity for Police FC in the recently concluded window.
Tooro United have only collected four points from 15 games and will have to double their efforts if they are to survive relegation.
Onduparaka FC are just a position above the relegation zone with 14 points.
The Caterpillars managed to register a point from their rescheduled game against KCCA at Bombo in a one all draw.
Former Tooro United captain Denis Ojera is the man to watch as he faces his former side.
Ojera was named the man of the match as his side Onduparaka FC shared spoils with KCCA in the previous tie.
Ronald Mubiru, Patrick Sserunjogi and Ponsiano are the other players that joined Onduparaka FC from Tooro United in the recently concluded transfer window.
Victory will have no impact on Tooro United as they will only move to seven points but will remain bottom of the table.
Maximum points can help the Caterpillars move to the 11th position.