Onduparaka recorded their first ever victory on a league opening day thanks to Vianne Sekajugo and Nicholas Sebwato.
Vianne Sekajugo catapulted the home side in the lead in the 27th minute heading home a well taken free kick from Nicholas Kagaba.
Nyamityobora tried to level matters through John Kisakye, Patrick Gonahasa and Lameck Ebong but their efforts were all futile.
In the 78th minute goalkeeper Nicholas Sebwato doubled the lead through a spot kick following foul play on Vianne Sekajugo in the forbidden area.
Nyamityobora FC defensive endeavors were dented by the absence of newly acquired defender Ibrahim Pengere who was not yet to cleared by the match kickoff.
Lameck Ebong and John Paul Achile both from Nyamityobora FC were cautioned in the 72nd and 76th minutes respectively.
The Caterpillars will return to action on Wednesday 3rd against SC Villa at Namboole while Nyamityobora will vie for points with Bright Stars at Wankulukuku on the same date.
Nicholas Sebwato (GK), Rashid Toha (C), Fred Agandu, Richard Ayiko, Rashid Okocha, Solomon Okwalinga, Oscar Agaba, Abel Eturude, Nicholas Kagaba, Vianne Sekajugo, Remex Kasozi
Richard Anyama (GK), Hassan Muhamood, Gaddafi Gadhino, Ezra Bida, Amis Muwonge, Kabon Living
Franco Oringa (GK), John Paul Achile, Henry Wamala (C) Benjamin Mpiire, Alex Komakech, John Wesley Kisakye, Martin Arinaitwe, Bruhan Matovu, Patrick Gonahasa, Charles Musiige, Lameck Ebong
Saddam Ogwang (GK), Joseph Akandwanaho, Brian Mugisha, Charles Sebutinde, David Kiiza.