Amir Zzake Kakomo and Benson Muhindo will leave SC Villa when their contracts expire at the end of June.
Swift Sports Uganda understands that the duo failed to reach an agreement with the club hierarchy over contract renewals.
Kakomo and Muhindo held several meetings with former Uganda Cranes captain Andy Mwesigwa who serves as Villa technical director over their future but they failed to reach a compromise.
Kakomo joined the Jogoos in 2018 after a brief stint at KCCA FC and has been one of the senior players at the record Uganda Premier league champions.
He is also a former Kiboga Young and Juventus Namasuba player. The midfielder played for Ssingo, Buwekula and Gomba in the prestigious Masaza Cup competition and featured for Nkozi University in the University Football league.
Muhindo is a Villa academy graduate and will also end his association with the club at the end of this month.
Last season, Villa finished 12th on the Uganda Premier league table with 33 points in 30 games.